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The transcription factor FoxO is central to this regulation, affecting cell proliferation, stress responses, apoptosis, and longevity. Introduction Life expectancy of an organism is influenced by its genetic makeup, as well as by extrinsic parameters, such as nutrition and oxidative stress. Gene regulatory mechanisms that control metabolism or the ability to fend off detrimental reactive oxygen species affect longevity of a wide variety of organisms. According to the current model, FoxO is inactivated by IIS in conditions of high nutrient availability and low environmental stress. IIS activation thus results in repression of FoxO target genes.
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Lukas Valenta Rinner Britni West In recent years, young filmmaker Lukas Valenta Rinner drily concludes, unease in the media concerning the impending end of the world has gradually increased — due perhaps in part to the devastating consequences of worldwide capitalism. Therefore, Rinner continues, it should not be difficult to come up with a tourism opportunity in which people prepare themselves for the end of the world in a natural environment, in fact then escaping from the demoralising routine of big city life. In his fiction debut, the Austrian director, who trained and lives in Argentina, sends a colourful group of middle-class Buenos Aires residents on a kind of boot camp in a resort in the nearby Tigre delta, where under the threat of the end of the world they become distanced from their humanitarian ideas and transform from citizens into predatory beasts.
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